Several days after the liquidation of Ghetto B, in late July or, probably, early August, 1942, several young Jews who had been working in various camps around Drohiczyn arived in the town. There they learned that their family members had been killed during the liquidation. Some of them said they wanted to take revenge against the Judenrat members for having sent their elderly parents to be shot. The Germans learned about this and ordered the Judenrat to hang them. Three young Jewish men were hanged by the Jewish police in the area of Ghetto A.
In mid-September or, probably, in early October, 1942, after speaking with a Judenrat member, the Germans shot him. Later on the same day fifteen more inmates of the Ghetto were shot, their possessions were confiscated, and the survivng Judenrat members were forced to sign a statement claiming that all the sixteen Jews had died from heart failure.

More information: Yad Vashem

On October 15, 1942 the Ukrainian police surrounded Ghetto A and its inmates were shot in ditches by SD soldiers, members of Police Battalion 306, Latvian volunteers, and Luftwaffe soldiers. The pits had been dug by ghetto inmates a month before the operation - on the pretext of providing shelter from bombing. According to some testimonies, the victims were forced to undress and were taken to the pits naked. The victims were probably shot in groups, with their arms tied together with wire. Most of the documents say that the murder site was in the area between the train station and the old Jewish cemetery, although Soviet documents identify the murder site as having been in the area of the cemetery next to the Drohiczyn county consumers' cooperative (Raypotrebsoyuz). According to some testimonies, for several days after the operation the police searched for hidden Jews and [when they found them] shot them in the same area. The number of the victims reported ranges from 1,500 in German documents to 3,816 in Soviet reports.

More information: Yad Vashem